TB-500 10mg
TB-500 10mg — for in vitro laboratory research use only.
Product Overview
TB-500 is a pharmaceutical-grade research compound supplied as a lyophilized powder. Each batch undergoes independent third-party testing with a Certificate of Analysis (COA) available on request.
Specifications
| Sequence | Peptide related to Thymosin Beta-4. Confirm the exact sequence against the batch Certificate of Analysis. |
| Classification | Peptide related to Thymosin Beta-4; supplied composition varies between suppliers |
| Appearance | White to off-white lyophilised powder (typical presentation) |
| Solubility | Soluble in sterile water or bacteriostatic water |
| Storage | Store lyophilised powder desiccated and protected from light at -20C. Once reconstituted, store at 2-8C for short-term use and avoid repeated freeze-thaw cycles. |
| Shelf Life | Typically stable for up to 24 months when stored lyophilised, desiccated, and protected from light at -20C. Confirm against the specific batch Certificate of Analysis. |
Description & Mechanism of Action
TB-500 is a trade name rather than a single defined molecule, and this matters when comparing products between suppliers. The peptide most commonly supplied under the name is Ac-LKKTETQ, an N-acetylated seven-amino-acid fragment corresponding to residues 17 to 23 of Thymosin Beta-4, a naturally occurring actin-regulating protein. Some suppliers instead supply the full-length 43-amino-acid Thymosin Beta-4, which has different molecular properties. Research interest centres on the actin-binding region of Thymosin Beta-4 and its role in sequestering G-actin and regulating actin polymerisation within cells, a mechanism studied in connection with the migration of endothelial cells, keratinocytes and stem cells toward sites of tissue damage. Because the two forms are not equivalent, the composition of any given batch should be confirmed against its own Certificate of Analysis rather than assumed from the product name.
Applications in Research
- Investigating actin-regulated cell migration in wound-healing research
- Research into G-actin sequestration and actin polymerisation dynamics
- Endothelial and keratinocyte migration models
- Comparative research between full-length Thymosin Beta-4 and shorter synthetic fragments
Handling, Reconstitution & Stability
- Handle as a hygroscopic powder; open vials and weigh under dry conditions where possible
- Reconstitute with sterile water or bacteriostatic water, adding solvent slowly down the side of the vial
- Swirl gently to dissolve. Avoid vigorous shaking.
- Filter-sterilise (0.22 micron) immediately before use if required by your protocol
- Aliquot reconstituted solution and store at -20C or below; avoid repeated freeze-thaw cycles
Precautions & Notes
- Peptides marketed as TB-500 vary in composition between suppliers. Confirm the actual sequence and purity against the batch Certificate of Analysis.
- Not approved as a medicine in any jurisdiction
- Experimental effects are concentration-, duration-, and model-dependent
- For laboratory research use only. Not for human or veterinary use.
This product is supplied for in vitro research purposes only. It is not intended for human or animal administration, diagnostic use, or any other purpose. Handle in accordance with good laboratory practice guidelines.