SS-31 50mg
SS-31 50mg — for in vitro laboratory research use only.
Product Overview
SS-31 is a pharmaceutical-grade research compound supplied as a lyophilized powder. Each batch undergoes independent third-party testing with a Certificate of Analysis (COA) available on request.
Specifications
| CAS Number | 736992-21-5 |
| Molecular Formula | C32H49N9O5 |
| Molar Weight | ~639.80 g/mol |
| Sequence | D-Arg-2',6'-dimethyltyrosine (Dmt)-Lys-Phe-NH2 |
| Classification | Synthetic mitochondria-targeted tetrapeptide (Szeto-Schiller peptide) |
| Appearance | White to off-white lyophilised powder (typical presentation) |
| Solubility | Soluble in sterile water or bacteriostatic water |
| Storage | Store lyophilised powder desiccated and protected from light at -20°C. Once reconstituted, store at 2-8°C for short-term use and avoid repeated freeze-thaw cycles. |
| Shelf Life | Typically stable for up to 24 months when stored lyophilised, desiccated, and protected from light at -20°C — confirm against the specific batch's Certificate of Analysis. |
Description & Mechanism of Action
SS-31 (elamipretide) is a synthetic tetrapeptide designed to selectively accumulate in the inner mitochondrial membrane by binding cardiolipin, a phospholipid found almost exclusively in that membrane. By binding cardiolipin, SS-31 is reported to prevent it from converting cytochrome c into a peroxidase, while helping preserve cytochrome c's normal electron-carrying function within the electron transport chain. This interaction has been associated with stabilisation of mitochondrial cristae structure and respiratory chain supercomplexes, reduced mitochondrial reactive oxygen species (ROS) production, and improved ATP synthesis and membrane potential in stressed cells, including cardiomyocytes and neurons in preclinical models. Because its mechanism centres on membrane electrostatics and cardiolipin binding rather than a classical receptor interaction, SS-31 is studied primarily as a tool for probing mitochondrial bioenergetics and oxidative stress rather than a conventional receptor-mediated pathway.
Applications in Research
- Studying cardiolipin-cytochrome c interactions and mitochondrial membrane electrostatics
- Mitochondrial cristae structure and respiratory supercomplex research
- Reactive oxygen species (ROS) and oxidative stress research models
- Cardiomyocyte and neuronal mitochondrial bioenergetics research
Handling, Reconstitution & Stability
- Handle as a hygroscopic powder; open vials and weigh under dry conditions where possible
- Reconstitute with sterile water or bacteriostatic water, adding solvent slowly down the side of the vial
- Swirl gently to dissolve — avoid vigorous shaking
- Filter-sterilise (e.g. 0.22 µm) immediately before use if required by your protocol
- Aliquot reconstituted solution and store at -20°C or below; avoid repeated freeze-thaw cycles
Precautions & Notes
- Experimental effects are concentration-, duration-, and model-dependent
- Include appropriate experimental controls to distinguish specific from non-specific effects
- For laboratory research use only — not for human or veterinary use
This product is supplied for in vitro research purposes only. It is not intended for human or animal administration, diagnostic use, or any other purpose. Handle in accordance with good laboratory practice guidelines.