Selank 10mg
Selank 10mg — for in vitro laboratory research use only.
Product Overview
Selank is a pharmaceutical-grade research compound supplied as a lyophilized powder. Each batch undergoes independent third-party testing with a Certificate of Analysis (COA) available on request.
Specifications
| CAS Number | 129954-34-3 |
| Molecular Formula | C33H57N11O9 |
| Molar Weight | ~751.90 g/mol |
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP) |
| Classification | Synthetic heptapeptide; stabilised analog of tuftsin |
| Appearance | White to off-white lyophilised powder (typical presentation) |
| Solubility | Soluble in sterile water or bacteriostatic water |
| Storage | Store lyophilised powder desiccated and protected from light at -20°C. Once reconstituted, store at 2-8°C for short-term use and avoid repeated freeze-thaw cycles. |
| Shelf Life | Typically stable for up to 24 months when stored lyophilised, desiccated, and protected from light at -20°C — confirm against the specific batch's Certificate of Analysis. |
Description & Mechanism of Action
Selank is a synthetic heptapeptide, a stabilised analog of tuftsin, an endogenous immunomodulatory peptide, developed to resist rapid enzymatic degradation. In rodent studies, intranasally administered Selank crosses the blood-brain barrier and has been shown to upregulate BDNF mRNA expression in the hippocampus, a brain region central to memory and emotional regulation. Selank has also been reported to inhibit enkephalin-degrading enzymes, prolonging the activity of endogenous enkephalins at the synapse, and to allosterically modulate GABA-A receptor sensitivity, enhancing inhibitory neurotransmission. Its tuftsin-derived origin has additionally directed research interest toward immune modulation, including effects on cytokine expression such as IL-6. The evidence base is predominantly from Russian rodent studies, with more limited independent international human-trial validation.
Applications in Research
- Investigating BDNF-mediated neuroplasticity and hippocampal gene expression
- Studying enkephalinase inhibition and GABAergic modulation
- Anxiolytic and nootropic research models
- Immunomodulatory research relating to tuftsin-derived signalling
Handling, Reconstitution & Stability
- Handle as a hygroscopic powder; open vials and weigh under dry conditions where possible
- Reconstitute with sterile water or bacteriostatic water, adding solvent slowly down the side of the vial
- Swirl gently to dissolve — avoid vigorous shaking
- Filter-sterilise (e.g. 0.22 µm) immediately before use if required by your protocol
- Aliquot reconstituted solution and store at -20°C or below; avoid repeated freeze-thaw cycles
Precautions & Notes
- Mechanism is based predominantly on Russian rodent studies, with limited independent international human-trial validation
- Experimental effects are concentration-, duration-, and model-dependent
- Include appropriate experimental controls to distinguish specific from non-specific effects
- For laboratory research use only — not for human or veterinary use
This product is supplied for in vitro research purposes only. It is not intended for human or animal administration, diagnostic use, or any other purpose. Handle in accordance with good laboratory practice guidelines.