Ipamorelin 10mg
Ipamorelin 10mg — for in vitro laboratory research use only.
Product Overview
Ipamorelin is a pharmaceutical-grade research compound supplied as a lyophilized powder. Each batch undergoes independent third-party testing with a Certificate of Analysis (COA) available on request.
Specifications
| CAS Number | 170851-70-4 |
| Molecular Formula | C38H49N9O5 |
| Molar Weight | ~711.87 g/mol |
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH2 |
| Classification | Synthetic pentapeptide; selective ghrelin receptor (GHS-R1a) agonist |
| Appearance | White to off-white lyophilised powder (typical presentation) |
| Solubility | Soluble in sterile water or bacteriostatic water |
| Storage | Store lyophilised powder desiccated and protected from light at -20°C. Once reconstituted, store at 2-8°C for short-term use and avoid repeated freeze-thaw cycles. |
| Shelf Life | Typically stable for up to 24 months when stored lyophilised, desiccated, and protected from light at -20°C — confirm against the specific batch's Certificate of Analysis. |
Description & Mechanism of Action
Ipamorelin is a synthetic pentapeptide and a selective agonist of the ghrelin receptor (GHS-R1a), structurally distinct from GHRH analogs such as tesamorelin. It binds GHS-R1a on pituitary somatotroph cells, triggering a Gq/11-mediated phospholipase C signalling cascade that raises intracellular calcium and drives exocytosis of stored growth hormone (GH). Its defining research characteristic is selectivity: in the landmark 1998 characterisation study, ipamorelin stimulated GH release without producing significant elevations in cortisol, prolactin, ACTH, FSH, LH or TSH — a selectivity profile that distinguished it from earlier, less selective growth hormone secretagogues such as GHRP-6. Because it acts through the ghrelin receptor rather than the GHRH receptor, ipamorelin is frequently studied alongside GHRH analogs (e.g. CJC-1295, tesamorelin) for their complementary, non-overlapping stimulation of the GH/IGF-1 axis.
Applications in Research
- Studying ghrelin-receptor (GHS-R1a) selectivity in GH secretagogue research
- Investigating Gq/PLC/calcium signalling in pituitary somatotrophs
- Comparative research alongside GHRH-pathway analogs
- GH/IGF-1 axis and body-composition research models
Handling, Reconstitution & Stability
- Handle as a hygroscopic powder; open vials and weigh under dry conditions where possible
- Reconstitute with sterile water or bacteriostatic water, adding solvent slowly down the side of the vial
- Swirl gently to dissolve — avoid vigorous shaking
- Filter-sterilise (e.g. 0.22 µm) immediately before use if required by your protocol
- Aliquot reconstituted solution and store at -20°C or below; avoid repeated freeze-thaw cycles
Precautions & Notes
- Human clinical data on ipamorelin remains limited relative to its animal-model research base
- Experimental effects are concentration-, duration-, and model-dependent
- Include appropriate experimental controls to distinguish specific from non-specific effects
- For laboratory research use only — not for human or veterinary use
This product is supplied for in vitro research purposes only. It is not intended for human or animal administration, diagnostic use, or any other purpose. Handle in accordance with good laboratory practice guidelines.