Epithalon 10mg
Epithalon 10mg — for in vitro laboratory research use only.
Product Overview
Epithalon is a pharmaceutical-grade research compound supplied as a lyophilized powder. Each batch undergoes independent third-party testing with a Certificate of Analysis (COA) available on request.
Specifications
| CAS Number | 307297-39-8 |
| Molecular Formula | C14H22N4O9 |
| Molar Weight | ~390.35 g/mol |
| Sequence | Ala-Glu-Asp-Gly (AEDG) |
| Classification | Synthetic tetrapeptide; pineal peptide bioregulator |
| Appearance | White to off-white lyophilised powder (typical presentation) |
| Solubility | Soluble in sterile water or bacteriostatic water |
| Storage | Store lyophilised powder desiccated and protected from light at -20°C. Once reconstituted, store at 2-8°C for short-term use and avoid repeated freeze-thaw cycles. |
| Shelf Life | Typically stable for up to 24 months when stored lyophilised, desiccated, and protected from light at -20°C — confirm against the specific batch's Certificate of Analysis. |
Description & Mechanism of Action
Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly), modeled on a naturally occurring peptide bioregulator of the pineal gland, developed through Russian peptide-bioregulator research beginning in the 1980s. Two distinct mechanisms have been proposed in the literature: first, induction of the telomerase catalytic subunit (TERT) in cultured human cells, reported to extend telomere length and, by extension, cellular replicative capacity; second, a pineal-signalling effect in which Epithalon upregulates phosphorylated CREB (pCREB), increasing expression of AANAT, the rate-limiting enzyme in melatonin biosynthesis, and thereby modulating circadian gene expression. A landmark rodent lifespan study reported a 12.3% increase in both mean and maximum lifespan in Epithalon-treated mice compared to controls. The evidence base for Epithalon is predominantly Russian preclinical and rodent research, with limited independent international human-trial validation.
Applications in Research
- Studying telomerase (TERT) induction and telomere-length maintenance
- Pineal gland and melatonin-synthesis (AANAT/pCREB pathway) research
- Rodent lifespan and aging-biomarker research models
- Circadian gene expression studies
Handling, Reconstitution & Stability
- Handle as a hygroscopic powder; open vials and weigh under dry conditions where possible
- Reconstitute with sterile water or bacteriostatic water, adding solvent slowly down the side of the vial
- Swirl gently to dissolve — avoid vigorous shaking
- Filter-sterilise (e.g. 0.22 µm) immediately before use if required by your protocol
- Aliquot reconstituted solution and store at -20°C or below; avoid repeated freeze-thaw cycles
Precautions & Notes
- Evidence base is predominantly Russian preclinical and rodent research, dating to the 1980s-90s, with limited independent international human-trial validation
- Experimental effects are concentration-, duration-, and model-dependent
- Include appropriate experimental controls to distinguish specific from non-specific effects
- For laboratory research use only — not for human or veterinary use
This product is supplied for in vitro research purposes only. It is not intended for human or animal administration, diagnostic use, or any other purpose. Handle in accordance with good laboratory practice guidelines.