5-Amino-1MQ 5mg
5-Amino-1MQ 5mg — for in vitro laboratory research use only.
Product Overview
5-Amino-1MQ is a pharmaceutical-grade research compound supplied as a lyophilized powder. Each batch undergoes independent third-party testing with a Certificate of Analysis (COA) available on request.
Specifications
| CAS Number | 42464-96-0 (iodide salt, as typically supplied) |
| Molecular Formula | C10H11N2+ (active cation); commonly supplied as the iodide salt, C10H11IN2 |
| Molar Weight | ~159.2 g/mol (cation); ~286.1 g/mol (iodide salt) |
| Classification | Small-molecule quinolinium compound; selective NNMT (nicotinamide N-methyltransferase) inhibitor |
| Appearance | Clear, colourless to pale yellow solution (typical presentation) |
| Solubility | Soluble in water |
| Storage | Store at room temperature, protected from light. Refrigerate after opening. |
| Shelf Life | Refer to the specific batch's Certificate of Analysis for shelf life when stored as directed. |
Description & Mechanism of Action
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that consumes nicotinamide and S-adenosylmethionine (SAM) to produce 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH). By inhibiting NNMT, 5-Amino-1MQ is reported to reduce this methylation "sink," increasing SAM availability for other cellular methylation reactions while freeing nicotinamide for recycling toward NAD+ via the NAMPT salvage pathway. The resulting increase in NAD+ availability has been studied for its support of redox and sirtuin-dependent pathways linked to mitochondrial function, lipid oxidation, and insulin action. In diet-induced obesity mouse models, selective NNMT inhibitors including 5-Amino-1MQ have been reported to reduce white adipose tissue mass and body weight and improve several metabolic parameters.
Applications in Research
- Studying NNMT enzyme inhibition and methyl-group metabolism
- NAD+ salvage pathway and sirtuin-linked research models
- Diet-induced obesity and adipose-tissue research
- Investigating SAM availability and cellular methylation capacity
Handling, Reconstitution & Stability
- Supplied as a solution — no reconstitution required
- Store as directed on the product label, protected from light
- Use aseptic technique when drawing from the vial to avoid contamination
Precautions & Notes
- Experimental effects are concentration-, duration-, and model-dependent
- Include appropriate experimental controls to distinguish specific from non-specific effects
- For laboratory research use only — not for human or veterinary use
This product is supplied for in vitro research purposes only. It is not intended for human or animal administration, diagnostic use, or any other purpose. Handle in accordance with good laboratory practice guidelines.